The Chinese University of Hong Kong Faculty of Medicine, The Chinese University of Hong Kong
Peter Hung Pain Research Institute
The Chinese University of Hong Kong
From Discovery to application

Research Projects

  • Completed Projects
  • Delivery of Magnetic Nanoparticles for Management of Pain
    Project Investigator:
    Professor Jonathan Choi, Professor, Department of Biomedical Engineering, Faculty of Engineering, CUHK
    Co-Investigators:
    • Professor Matthew Chan, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Lin Zhi-xiu, Director and Professor, School of Chinese Medicine, Faculty of Medicine, CUHK
  • Probiotics and their Metabolites for Treating Chronic Pain
    Project Investigator:
    Professor William Wu, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Matthew Chan, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
  • Development of a Non-invasive and Effective Electromagnetic Neural Modulation System for Pain Patients
    Project Investigator:
    Professor Zhang Li, Professor, Department of Mechanical and Automatic Engineering, Faculty of Engineering, CUHK
    Co-Investigators:
    • Professor Chan Kai-fung, Tony, Research Assistant Professor, Chow Yuk Ho Technology Center for Innovative Medicine, Faculty of Medicine, CUHK
    • Mr Edwin Yu, PhD Candidate, Department of Mechanical and Automatic Engineering, Faculty of Engineering, CUHK
  • Electroencephalography-assisted Prefrontal Cortex Stimulation via Temporally Interfering Electric fields: a Novel Non-invasive Approach to Neuropathic Pain Treatment
    Project Investigator:
    Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Wang Jie, Professor, Division of Magnetic Resonance Imaging, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan
    • Professor Bao Qing-jia, Associate Professor, Division of Precision Scientific Instrumentation, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan
    • Professor Tian Xue-bi, Professor, Department of Anesthesiology, Tongji medical college, Huangzhong University of Science and Technology, Wuhan
  • Development of a Novel Chinese Medicine Formula for the Treatment of Gout: Preclinical Evaluation on Its Efficacy, Safety and Molecular Mechanisms
    Project Investigator:
    Professor Lin Zhi-xiu, Director and Professor, School of Chinese Medicine, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Matthew Chan, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Xian Yan-fang, Lisa, Assistant Professor, School of Chinese Medicine, Faculty of Medicine, CUHK
    • Dr Wang Lan, Post-doctoral fellow, School of Chinese Medicine, Faculty of Medicine, CUHK
  • Gut Microbiota in Adults with Chronic Widespread Pain: a Pilot Case-control Study
    Project Investigator:
    Professor Sit Wing-shan, Regina, Associate Professor (Clinical), The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Francis Chan, Choh-Ming Li Professor of Medicine and Therapeutics, Faculty of Medicine, CUHK
    • Professor Siew Ng, Assistant Dean (Development), Faculty of Medicine, CUHK
    • Professor Zhang Lin, Assistant Professor, Department of Medicine and Therapeutics, Faculty of Medicine, CUHK
    • Professor Hein Tun, Associate Professor, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, CUHK
  • Current Projects
  • Innovative Drug Discovery from (2R,6R)-Hydroxynorketamine for the treatment of chronic pain
    Project Investigator:
    Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Billy Ng, Assistant Professor, School of Pharmacy, Faculty of Medicine, CUHK
    • Professor Zhou Wen-jie, Professor, Songjiang Institute, Shanghai Jiao Tong University
    • Professor Tan Tao, Professor, Oujiang Laboratory
  • Development and Preclinical Evaluation of a Novel MNT Targeted Therapy for Cancer Pain
    Project Investigator:
    Professor Patrick Tang, Associate Professor, Department of Anatomical and Cellular Pathology, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Cynthia Jiang, Associate Professor, School of Biomedical Sciences, Faculty of Medicine, CUHK
    • Professor Dongmei Zhang, Dean, College of Pharmacy, Jinan University
    • Professor David Nikolic-Paterson, Professor, Centre for Inflammatory Disease Monash Health, Monash University
  • Shingles and PHN: Decoding the Pain with Immune Clues and AI
    Project Investigator:
    Professor Likai Tan, Research Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Zhang Wei-bo, Professor and Chief Physician, Department of Anesthesia and Pain Management, Zhejang University
  • Development of Joint Pain Medications Using Innervated Joint-on-a-Chip Systems
    Project Investigator:
    Professor Alan Li, Vice-Chancellor Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, CUHK
    Co-Investigators:
    • Professor Rocky S. Tuan, Professor, Institute for Tissue Engineering and Regenerative Medicine (iTREM), School of Biomedical Sciences, Faculty of Medicine, CUHK
    • Professor Yong Chen, CNRS Research Director (Emeritus), Head of the Laboratory for Microfluidic, École Normale Supérieure
  • Self-therapeutic gold nanoparticles for alleviating peripheral neuropathic pain
    Project Investigator:
    Professor Jonathan Choi, Professor, Department of Biomedical Engineering, Faculty of Engineering, CUHK
    Co-Investigators:
    • Professor Matthew Chan, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor William Wu, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
  • Butyrate and Taurine to reduce chronic postsurgical pain in adult cardiac surgical patients: a Bayesian Optimized double-blinded randomized controlled trial
    Project Investigator:
    Professor Henry Wong, Assistant Professor (Clinical), Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Dr. Ranjith Kumar Sivakumar, Clinical Lecturer, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Dr. Ara Cheuk Yin Li, Consultant, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
  • ProEGCG, a novel prodrug of epigallocatechin-3-gallate (EGCG) from green tea, as an effective, safe treatment for women suffering from endometriosis and menstrual pain
    Project Investigator:
    Professor Ronald Wang, Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Matthew Chan, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Dr. Hung Sze Wan Kennes, Postdoctoral Fellow, Department of Obstetrics and Gynaecology, Faculty of Medicine, CUHK
    • Prof. Zhang Tao, Research Assistant Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, CUHK
    • Prof. Chung Pui Wah, Jacqualine, Associate Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, CUHK
  • Effects of GABA with Butyrate and GABA/Butyrate-producing Synbiotics on Pain Relief in Fibromyalgia: A Phase II, Multi-Centered, Double-Blinded, Randomized-Controlled Trial (Fibro-Relief Trial)
    Project Investigator:
    Professor Mandy Chu, Assistant Professor (Clinical), Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Dr. Ara Cheuk Yin Li, Consultant, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Dr. Eric Ng, Associate Consultant, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Dr. Debriel Yin Ling Or, Consultant, Department of Anaesthesiology, Pain Management Center, NTEC
    • Dr. Sandy Yee Chi Lee, Consultant, Department of Anaesthesiology, Pain Management Center, NTEC
    • Dr. Alfred Chor San Chan, Associate Consultant, Department of Anaesthesia, Pamela Youde Nethersole Eastern Hospital
    • Dr. Janice Chun Ying Liu, Associate Consultant, Department of Anaesthesia, Pamela Youde Nethersole Eastern Hospital
    • Dr. Man Shun Law, Consultant, Department of Anaesthesia and Operating Theatres, Kwong Wah Hospital
    • Dr. Aaron Chee Lun Ying, Consultant, Department of Anaesthesia and Operating Theatre Services, Tuen Mun Hospital
    • Dr. Charmaine Ka Lai Chu, Consultant, Department of Anaesthesiology, Pain Medicine and Operating Service, United Christian Hospital
    • Dr. Huey Sing Lim, Department of Anaesthesiology, Pain Medicine and Operating Service, United Christian Hospital
    • Dr. Wing Sang Chan, Consultant, Pain Specialist Clinic, CUHK Medical Centre
    • Professor William Wu, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Huarong Chen, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
  • Predicting and Preventing Postherpetic Neuralgia Using Microbiome Modules and Gut-Brain Network Mechanisms
    Project Investigator:
    Professor Likai Tan, Research Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Liu Xiao-dong, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Kong Yazhuo, Professor, Institute of Psychology, Chinese Academy of Sciences
    • Professor Liao Lijun, Professor, Tongji University Affiliated East Hospital
    • Professor Mandy Chu, Assistant Professor (Clinical), Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
  • Microbiota Therapy to Alleviate LPS-induced Pain in Fibromyalgia Patients
    Project Investigator:
    Professor Thomas Hitch, Assistant Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    Co-Investigators:
    • Professor Ho Kwok Ming, Chairman and Professor, Department of Anaesthesia and Intensive Care
    • Professor William Wu, Professor, Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK
    • Professor Mandy Chu, Assistant Professor (Clinical), Department of Anaesthesia and Intensive Care, Faculty of Medicine, CUHK